Retinal Function Abnormalities in Patients Treated With Vigabatrin
نویسندگان
چکیده
منابع مشابه
Retinal function abnormalities in patients treated with vigabatrin.
OBJECTIVE To evaluate central and peripheral retinal function in patients treated with vigabatrin, an antiepileptic drug associated with peripheral visual field constriction (VFC). METHODS Six patients with epilepsy treated with vigabatrin as add-on therapy for at least 3 years were included in this observational case series. All patients underwent a clinical ophthalmologic examination, color...
متن کاملOuter retinal dysfunction in patients treated with vigabatrin.
OBJECTIVE To assess early visual impairment related to vigabatrin prospectively in patients with and without visual symptoms. BACKGROUND Vigabatrin acts as an inhibitor of gamma-aminobutyric acid (GABA) transaminase. GABA-induced ion transport changes in the retinal pigment epithelium have been described. The electro-oculogram (EOG) is a clinical test that reflects photoreceptor and pigment e...
متن کاملA controlled study comparing visual function in patients treated with vigabatrin and tiagabine.
OBJECTIVE Vigabatrin treatment is frequently associated with irreversible retinal injury and produces retinal electrophysiological changes in nearly all patients. Concern has been raised that tiagabine and other antiepilepsy drugs (AEDs) that increase brain gamma-aminobutyric acid (GABA) might produce similar electrophysiological and clinical changes in visual function. The study compared visua...
متن کاملEpilepsy patients treated with vigabatrin exhibit reduced ocular blood flow.
BACKGROUND/AIM Reduced cerebral blood flow and decreased glucose metabolism have been identified in epilepsy patients receiving vigabatrin. It is likely that such a change may extend to the eye and may be linked to previously reported irreversible visual field defects. The aim of this study was to determine whether patients who have undergone anti-epileptic drug (AED) therapy with vigabatrin ha...
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Purpose: Surgeons performing an ilioinguinal exposure for acetabular fracture surgery need to be aware of aberrant findings such as inguinal hernias and spermatic cord lesions. The purpose of this study is to report these occurrences in a clinical series of adult males undergoing acetabular fracture fixation and a series of adult male cadavers. The secondary aim is to characterize these abnorma...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2003
ISSN: 0003-9950
DOI: 10.1001/archopht.121.6.811